Barcelona 2013
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| Abstract #84 - E-Posters English | ||||
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Session: 50.89: E-Posters English (Poster) on Sunday in Chaired by Authors: Presenting Author: Dr. Rana Aslanov - Memorial nUniversity of Newfoundland, Canada |
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| Additional Authors: Dr. Jordi Casabona, Sra Cristina Sanclemente, Dra. Anna Esteve, Dra. Victoria Gonzalez, Grupo HIVITS TS, | ||||
| Aim: Data regarding the incidence of HPV-caused anal, oropharyngeal and cervical malignancy in HIV-HCV co-infected population are limited. To evaluate the risk of malignancy associated with Human Papillomavirus infection in the population of interest, a systematic literature search, review and critical appraisal of evidence were performed to provide an extensive descriptive summary of all studies available on risk profile and the incidence of non-AIDS-defining HPV-related cancers. | ||||
| Method / Issue: To complete this research project, the knowledge synthesis (KS) for the purpose of ?knowledge development? and ?knowledge support? was conducted using Medline, EMBASE and the Cochrane library databases from 1980 to 2012. Data collection was based on the sensitive search strategy identifying studies that potentially met the study?s inclusion criteria and were published on English. Data collection process underwent the following selection steps: reading titles, reading abstracts and finally, reading articles. The references of the reviewed articles were also scanned for other relevant studies. Single studies and systematic reviews with the consistent results presented as average effects (e.g. SIRs, ORs, HRs and RRs) were included in this assessment. | ||||
| Results / Comments: The original broad search identified a total of 151 potentially relevant papers, of them, 9 articles were included in this analysis. Descriptive integration of the review findings suggest that the prevalence of some traditional risk factors for cancer, such as cigarette smoking, drug and alcohol abuse, and co-infection with HCV is two-three times higher among people infected with HIV as compared to the general population. The immune deficiency is the most probable and stronger explanation for the increased risk of non-AIDS-defining malignancies (NADCs). This increased risk in HIV infected and HIV/HCV co-infected populations is complex, heterogeneous and defined by multiple factors. | ||||
| Discussion: The number of cancers and types of cancers among HIV-positive people changed dramatically since introduction of HAART in 1996. People diagnosed with AIDS who are at the highest risk for malignancies, now represent an increasing minority of HIV-positive population The findings from the review showed that although, there are scarcity of data exist and the reviewed literature is often conflicting, it appears clear that people infected with HIV and co-infected with HCV are at an extended risk for a variety of NADCs, including all HPV-associated anogenital and oral cancers as well as their in situ precursor lesions. The review allowed gathering the recommendations that might be discussed and find helpful in the prevention and early detection of NADCs in the populations at the heightened risk for them. | ||||
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